ADDISON'S DISEASE
ADDISON'S DISEASE It is also known as PRIMARY ADRENAL INSUFFICIENCY / HYPOCORTISOLISM It is a long term endocrine disorder in which the adrenal glands do not produce enough steroid hormone(cortisol and aldosterone) Leading cause → Autoimmune destruction most common cause in india → Tuberculosis of adrenals CLINICAL FEATURES : Aldosterone decrease resulting in : Salt wasting , craving for salty foods polyuria (urine output >3L/day) postural hypotension hyperkalemia metabolic acidosis Cortisol decrease resulting in : cortisol deficiency results in decreased blood sugar → palpitations,tremors,diaphoresis,RAGE attack,emotional fragility ACTH increased : Have partial melanocyte stimulating hormone like action resulting in Hyperpigmentation at palmar / sole creases scars / areola / axilla / cubital fossa groin area oral mucosa nails DHEAS (Dehydroepiandrosterone sulfate) decreased resulting in : decrease libido er...