NEPHRITIC SYNDROME
NEPHRITIC SYNDROME It is a syndrome comprising signs of nephritis, which is kidney disease involving inflammation. it often occurs in the glomerulus, which is called glomerulonephritis Vasculitis - GFR decreased and renin increased leading to - Hypertension - Hematuria - Sub nephrotic proteinuria POST STREPTOCOCCAL GLOMERULONEPHRITIS (PSGN) Type III Hypersensitivity reaction Immunological manifestation seen with nephritogenic stain - streptococcus Antigen - streptococcal pyrogenic exotoxin B (SPEP) Immune complex (+) - complement mediated vasculitis PSGN - begin as impetigo or pharyngitis Hematuria cola coloured urine - smoky urine(freshly voided sample) Hypertension - sudden onset - left ventricular failure Dyspnea - pulmonary edema Renal insufficiency leading to feature of uremia WORKUP: Urine microscopic - >3 RBC/HPF (high power field) - RBC casts - Dysmorphic RBC - always indicate glomerular bleeding C3 decreased, CH50...