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LIDDLE SYNDROME It is a rare hereditary disorder involving increased activity of the epithelial sodium channel (ENaC) Autosomal dominant FEATURES: Gain salt and water leads to HYPERTENSION Hypokalemic alkalosis HYPERTENSION → Feedback RAAS: ↓Renin,↓Aldosterone (low renin hypertension) Dehydration: absent TREATMENT: Amiloride