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LIDDLE SYNDROME It is a AUTOSOMAL DOMINANT disorder It involving increased activity of the epithelial sodium channel(ENaC) Causes hypertension → negative inhibition of RAAS( renin angiotensin aldosterone system) system → renin decreased → aldosterone decreased  By this feedback mechanism aldosterone levels are decreased but hypertension occur due to excess salt and water in the body secondary to excessive activity of epithelial sodium channel Imaging : shows normal adrenal gland DOC : AMILORIDE (inhibit function of epithelial sodium channel

LIDDLE SYNDROME It is a rare hereditary disorder involving increased activity of the epithelial sodium channel (ENaC) Autosomal dominant FEATURES: Gain salt and water leads to HYPERTENSION Hypokalemic alkalosis HYPERTENSION → Feedback RAAS: ↓Renin,↓Aldosterone (low renin hypertension) Dehydration: absent TREATMENT: Amiloride