HYPERALDOSTERONISM
HYPERALDOSTERONISM It is a medical condition wherein too much aldosterone is produced by adrenal gland Hyperaldosteronism can be "primary" and "secondary" Primary hyperaldosteronism Excess production of aldosterone due to Bilateral adrenal hyperplasia (most common cause) Adrenal adenoma(tumor in the first layer of cortex)→ CONN'S SYNDROME Features: increase aldosterone cause more stimulation of epithelium sodium channel (E NaC) resulting in Increase sodium and water absorption resulting in expansion of plasma volume contralateral urinary loss of potassium and hydrogen clinical features: Headache due to hypertension Urinary loss of potassium(hypokalemia) resulting in muscle cramps(weakness) metabolic alkalosis due to loss of hydrogen ions gain of water in the body → expansion of plasma volume which increase venous return → ANF release(atrial natriuretic factor)→ natriuresis(loss of water) so, gain of water = loss of water(...