RENAL TUBULAR ACIDOSIS
RENAL TUBULAR ACIDOSIS (RTA) It is a medical condition that involves an accumulation of acid in the body due to a failure of kidneys to appropriately acidify the urine RTA - 1 Distal convoluted tubule (DCT) involved alpha(α) interrelated cells responsible for hydrogen(H+) excretion beta(β) interrelated cells responsible for bicarbonate excretion - In RTA - 1, α (alpha) interrelated cells are not working Impaired H+ excretion impaired NH4CL (ammonium chloride) excretion salt wasting ➝ increase aldosterone Hypokalemia metabolic acidosis which impair tubular reabsorption of calcium leading to NEPHROCALCINOSIS CAUSES Multiple myeloma Scleroderma Amphotericin B TREATMENT Oral soda bicarbonate RTA - 2 PCT(Proximal convoluted tubules) involved associated with Fanconi syndrom characterized by - Bicarbonaturia - salt wasting - polyuria - aminoaciduria - glucosuria - phosphaturia ETIOLOGY Multiple myeloma wilsons disease expi...