HYPOTHYROIDISM
Hypothyroidism(underactive thyroid) is a condition in which thyroid gland doesn't produce enough thyroid hormone PRIMARY HYPOTHYROIDISM Thyroid gland is involved T4 DECREASED , T3 DECREASED , TSH INCREASED(T4↓,T3↓,TSH↑) CAUSES : INDIA most common cause HASHIMOTO THYROIDITIS , GLOBALLY - ENDEMIC GOITER ENDEMIC CRETINISM - Body with hypothyroidism since birth Food goitrogen - cabbage , Drug induced hypothyroidism : Amiodarone SECONDARY HYPOTHYROIDISM Pituitary gland is involved T4 DECREASED , T3 DECREASED , TSH DECREASED(T4↓,T3↓,TSH↓) CAUSES : SHEEHAN SYNDROME (Pituitary infarction) Non obstetric cause of pituitary damage called as simmond's disease - occurs due to AVM rupture ,HTN , Trauma , sickle cell anemia Cranial radiation/sarcoidosis Empty sella syndrome / CSF leak syndrome CLINICAL FEATURES : Cold intolerance Myxedema (alopecia , puffy face , Hoarseness voice , thick coarse skin , constipation) Menorrhagia and infertility Headache Galactorrhea (...