MINIMAL CHANGE DISEASE
MINIMAL CHANGE DISEASE It is also "minimal change glomerulopathy" or nil disease It is a disease affecting the kidneys which causes a nephrotic syndrome most common cause of nephrotic syndrome in children common age 2 - 8 yrs CLINICAL FEATURES: Puffy eyes vulval edema/scortal edema, pedal edema weight gain ++ Oncotic pressure decreased - albumin decreased - Selective proteinuria - pleural effusion bilateral(Transudative) - dyspnea - Ascites - Abdominal girth increased, everted umbilicus WORKUP: BUN/creatinine - normal urine microscopic - Oval fat bodies 24hrs urine protein increased urine protein electrophoresis C3 levels normal/decreased kidney biopsy - light microscopic - normal electron microscopic - podocytes - foot process effacement TREATMENT: Steroid - prednisolone 8weeks (Taper dose), good response and hence ca...