HEPATITIS C
HEPATITIS C It is an infectious disease caused by the hepatitis c virus (HCV) that primarily affects the liver. most common cause of transmission is parenteral IV drug abusers(IVDA) > B T (blood transfusion) 90% cases of hepatitis C develops chronic hepatitis ↓↓↓↓ Activation of stellate cells ↓↓↓↓ cirrhosis - E.S.L.D (end stage liver disease) ↓↓↓↓ Liver transplant (most common cause for liver transplant in world is HCV induced cirrhosis) Investigation of choice(IOC) : E.I.A (enzyme immuno assay) anti HCV antibody PCR HCV RNA : "no cut off" for management of patient TREATMENT: Treatment based on Genotype Genotype 1: DOC - Ledipasvir Genotype 2: Sofosbuvir + Ribavirin Note: Pegylated interferon + Ribavirin (older)