POLYCYSTIC KIDNEY DISEASE
POLYCYSTIC KIDNEY DISEASE It is a genetic disorder, resulting in the development and growth of multiple cysts within the kidney Autosomal dominant polycystic kidney disease (ADPKD) - 75% Chances of expression in next generation Autosomal recessive polycystic kidney disease (ARPKD) - 25% Chances of expression in next generation chromosome 16 PKD1 gene defect - polycystin 1 protein affected chromosome 4 PKD2 gene defect - polycystin 2 protein affected Multiple cysts present both in medulla and cortex Renomegaly and progressive development of cyst occurs Development of bleeding in cyst can occur and which can cause flank pain CLINICAL FEATURE: Usual age of presentation = 30 -45 years Flank pain (due to stone formation, bleeding in cyst ) UTI(urinary tract infection): higher (chance of pyelonephritis) stones incidence higher : Urate stones can develop Renal cell cancer (RCC) : Bilateral, multicentric GFR decreased ( due to cyst) renin con...