zollinger ellison syndrome
zollinger ellison syndrome It is also known as GASTRINOMA it is a disease in which tumor cause the stomach to produce too much acid. Tumor of G cells most common site of G cells is stomach but gastrinoma occur most commonly in DUODENUM > PANCREAS > STOMACH also can present in a rare site as ovary , testis , heart Tumor lead to gastrin ++++ which leads to ulcers characterized by hypergastrinemia and hyperchlorhydria (recurrent peptic ulcer) 25% cases have association with MEN 1 (multiple endocrine neoplasia type 1) can be pituitary adenoma, parathyroid adenoma , pancreatic adenoma most common MEN 1 overall pancreatic adenoma is zollinger ellison syndrome clinical features: usual age of presentation 30 - 50 years (female > males) abdominal pain (epigastric pain) - hunger pain present diarrhea(due to excess acid production inactivate pancreatic enzymes) GERD (cause reflux esophagitis, retrosternal pain) past medical histor...