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ACROMEGALY It is a disorder that results from excess growth hormone (GH) after the growth plates have closed (excess GH after puberty) It is a diseases of anterior pituitary Somatotrophs are abundant cells in pituitary somatotroph adenoma is most common cause of developing Acromegaly Mammosomatotroph adenoma growth hormone and prolactin increases clinical features : Galactorrhea Leading cause of extra pituitary source of excess growth hormone → pancreatic adenoma (islet cells tumor) Leading cause of excessive GHRH production → CARCINOID TUMOR CLINICAL FEATURES : ACRAL ENLARGEMENT : Increase in size of hand/feet Increase in finger thickness leading to spade like hands Lower Jaw prominence called as Prognathism Frontal Bossing Heel pad thickness >21 mm → used for monitoring growth in these patients Coarse facies / deep hollow voice ,Hyperhidrosis(excessive sweating) , sebum increase (increase incidence of acne) , ac...

SHEEHAN SYNDROME It is also known as SIMMOND'S SYNDROME / POSTPARTUM HYPOPITUITARISM / POSTPARTUM PITUITARY GLAND NECROSIS Postpartum hemorrhage ↓ causes pituitary damage ↓ results in secondary addison's disease Results in decrease ACTH ↓ decrease cortisol ↓ Hypoglycemia Blood pressure is normal as aldosterone is not affected No hyperpigmentation as ACTH levels are low TREATMENT: DEXAMETHASONE

WATERHOUSE-FRIDERICHSEN SYNDROME It is also known as HEMORRHAGIC ADRENALITIS / FULMINANT MENINGOCOCCEMIA It is defined as adrenal gland failure due to bleeding into the adrenal glands,commonly caused by severe bacterial. It is caused by Neisseria Meningitidis / Pseudomonas Leads to Sepsis DIC (Disseminated intravascular coagulation) → adrenal hemorrhage → leading to Addisonian crisis TREATMENT : I.V  Hydrocortisone + Antibiotics + Fluid replacement

ADDISON'S DISEASE It is also known as PRIMARY ADRENAL INSUFFICIENCY / HYPOCORTISOLISM It is a long term endocrine disorder in which the adrenal glands do not produce enough steroid hormone(cortisol and aldosterone) Leading cause  → Autoimmune destruction most common cause in india → Tuberculosis of adrenals CLINICAL FEATURES : Aldosterone decrease resulting in : Salt wasting , craving for salty foods polyuria (urine output >3L/day) postural hypotension hyperkalemia metabolic acidosis Cortisol decrease resulting in : cortisol deficiency results in decreased blood sugar → palpitations,tremors,diaphoresis,RAGE attack,emotional fragility ACTH increased : Have partial melanocyte stimulating hormone like action resulting in Hyperpigmentation at palmar / sole creases scars / areola / axilla / cubital fossa groin area oral mucosa nails DHEAS (Dehydroepiandrosterone sulfate) decreased resulting in : decrease libido er...

LIDDLE SYNDROME It is a AUTOSOMAL DOMINANT disorder It involving increased activity of the epithelial sodium channel(ENaC) Causes hypertension → negative inhibition of RAAS( renin angiotensin aldosterone system) system → renin decreased → aldosterone decreased  By this feedback mechanism aldosterone levels are decreased but hypertension occur due to excess salt and water in the body secondary to excessive activity of epithelial sodium channel Imaging : shows normal adrenal gland DOC : AMILORIDE (inhibit function of epithelial sodium channel

HYPERALDOSTERONISM It is a medical condition wherein too much aldosterone is produced by adrenal gland Hyperaldosteronism can be "primary" and "secondary" Primary hyperaldosteronism Excess production of aldosterone due to Bilateral adrenal hyperplasia (most common cause) Adrenal adenoma(tumor in the first layer of cortex)→ CONN'S SYNDROME   Features: increase aldosterone cause more stimulation of epithelium sodium channel (E NaC) resulting in Increase sodium and water absorption resulting in expansion of plasma volume contralateral urinary loss of potassium and hydrogen clinical features: Headache due to hypertension Urinary loss of potassium(hypokalemia) resulting in muscle cramps(weakness) metabolic alkalosis due to loss of hydrogen ions gain of water in the body → expansion of plasma volume which increase venous return → ANF release(atrial natriuretic factor)→ natriuresis(loss of water) so, gain of water = loss of water(...

HEPATITIS D It is a disease caused by the HEPATITIS DELTA VIRUS (HDV) A small spherical enveloped virusoid Weak virus → for eradication 100% coverage of population with HBV vaccine should be done Route of spread - parenteral Transmission of HDV can occur either simultaneous infection with HBV (coinfection) or superimposed on chronic hepatitis B or hepatitis B carrier state (superinfection)