HEPATITIS C

HEPATITIS C

  • It is an infectious disease caused by the hepatitis c virus (HCV) that primarily affects the liver.



  • most common cause of transmission is parenteral
IV drug abusers(IVDA) > B T (blood transfusion)

90% cases of hepatitis C develops chronic hepatitis
↓↓↓↓
Activation of stellate cells
↓↓↓↓
cirrhosis - E.S.L.D (end stage liver disease)
↓↓↓↓
Liver transplant 
(most common cause for liver transplant in world is HCV induced cirrhosis)

  • Investigation of choice(IOC) : E.I.A (enzyme immuno assay) anti HCV antibody
  • PCR HCV RNA : "no cut off"  for management of patient


TREATMENT:

Treatment based on Genotype
  • Genotype 1: DOC - Ledipasvir
  • Genotype 2: Sofosbuvir + Ribavirin
Note: Pegylated interferon + Ribavirin (older)

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